Histiocytic medullary reticulosis is a ratr disease and first described by scott and Robb-Smith in 1939, that is characterized by acute onset and invariably fatal outcome with weeks or months of diagnosis. Major clinical features are fever,
malaise,
weakness, weight loss, lymphadenopathy, hepatosplenomegaly, jaundice and purpura. Common laboratory findings are severe anemia, leukopenia and thrombocytopenia. Cardinal pathologic features are systemized proliferation of atypical, neoplastic,
erythrophagocytic histiocytes.
Bone marrow aspirates and biopsies from involved tissues(liver, spleen, lymph node) were found best suited for establishing the diagnosis. recently we experienced one case of HMR who was a 16-year-old male with first impression of chronic active
hepatitis. The purpose of this report is to illutrate pertinent clinical and pathological features of this case and to review the previous literatures.
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